Events

Single Cell NGS Webinar:
Expert Advice on Sample Prep Protocols for Single-Cell Biology Research

Mon June 20 at 4 pm CEST (7 am PT)

This webinar will provide a scientist’s perspective on the importance of sample preparation protocols for single-cell biology research.

New single-cell technologies have facilitated deeper exploration of inter- and intratumor heterogeneity than previously possible, but before any downstream analyses, cells need to be processed into suspensions that are free of debris and aggregates.

Register

Preserving original cell biology and eliminating interfering debris as much as possible across applications is crucial to overall data quality and reproducibility. This webinar will discuss automation solutions and other sample prep protocols that will help you ensure better, standardized sample preparation for fluorescence-based assays.

Curiox Laminar Wash
Curiox Laminar Wash webinar
Curiox logo

Single-Cell Multi-Omics for Hematologic Malignancies Research

Thursday June 16 2 pm CEST

Join Mission Bio & the Josep Carreras Leukaemia Research Institute for an interactive virtual seminar highlighting the key advantages of single-cell technology that simultaneously measures single-nucleotide variation (SNV), copy number variation (CNV), and protein data from the same cells. Our multi-omics platform connects genotype and phenotype in each cell, dissecting the architecture of tumors with unprecedented resolution.

We are happy to welcome Dr. Manel Esteller, Director of Josep Carreras Leukaemia Research Institute (IJC). He will present data from his institute on epigenome and epi-transcriptome maps of  normal and transformed cells of leukemia and other malignant blood diseases.

In addition, Simone Formisano will give an introduction to Mission Bio’s Tapestri capabilities on SNV, CNV, and protein sequencing at scale, the workflow and its applications in oncology and cell and gene therapy.

Speakers:
Dr. Manel Esteller, Josep Carreras Leukaemia Research Institute (IJC), Barcelona

Simone Formisano
Technical Application Liaison
Mission Bio.

Register

MissionBio Tapestri
MissionBio hematology

Bringing a New Standard of Clarity to Solid Tumor Research With Single-Cell Genomics

Thursday June 16 11 am EDT

A major challenge to combating cancer is the dynamism and inherent heterogeneity contributing to the disease’s onset, progression, and relapse. In the enormous efforts to identify the factors underlying these factors, bulk sequencing is widely used, but the need for unmasking the underlying genetic diversity across cell populations remains unmet.

Single-cell DNA sequencing can be used to interrogate clonal mosaicism and neoplastic transformation, metastatic dissemination, and therapeutic resistance with its ability to co-analyze SNVs and CNVs at the single-cell level in a scalable manner. As a tool for probing clonal architecture and evolution, researchers can identify zygosity, mutational co-occurrence, and rare mutations in individual cells.

Jorge Reis-Filho of Memorial Sloan Kettering Cancer Center will share the strategies for characterizing intratumor heterogeneity and evolutionary trajectories in cancers at the single-cell level and present his latest findings in breast cancer research.

This webinar will also present the latest advances in single-cell DNA sequencing, including pre-designed solid tumor DNA panels, single-cell CNV analysis workflow, and nuclei isolation protocols enabling solid tumor researchers to access this technology.

Attendees will:

  • Learn how single-cell DNA sequencing can bring a new level of clarity to research in solid tumors, such as breast cancer, by providing insights into the clonal architecture, mutation co-occurrence, and rare mutations driving tumor progression and therapy resistance.
  • Discover the science behind the Tapestri single-cell sequencing platform.
  • Hear about case studies and implementation considerations, including cell and nuclei prep, panel design, and analysis.

Presenter:
Jorge Reis-Filho, MD, PhD, FRCPath, Chief, Experimental Pathology Service Memorial Sloan Kettering Cancer Center

Register

MissionBio solid tumor

Unleashing the Power of Single-Cell Multi-Modal Analysis to Advance Precision Biology

Tuesday May 10 at 15:00 CET

Join Mission Bio for an interactive virtual seminar highlighting the key advantages of single-cell technology that simultaneously measures single-nucleotide variation (SNV), copy number variation (CNV), and protein data from the same cells. Our multi-omics platform connects genotype and phenotype in each cell, dissecting the architecture of tumors with unprecedented resolution.

We are happy to welcome Dr. Kendell Clement, Instructor in Pathology at the Massachusetts General Hospital who will present at this seminar.

In addition, Simone Formisano will give a short introduction to Mission Bio’s Tapestri capabilities on SNV, CNV, and protein sequencing at scale, the workflow and its applications in oncology and cell and gene therapy.

Signup

Mission Bio logotype

CHIP’ing away at somatic mosaicism — Diving into the promises and challenges of characterizing clonal hematopoiesis of indeterminate potential

Friday April 22 11:30 am EDT

CHIP (clonal hematopoiesis of indeterminate potential) is a non-malignant condition characterized by mutational and clonal expansion of hematopoietic stem cells, beginning at middle age. Though CHIP is not considered a disease, it is associated with a higher risk for several diseases including hematological malignancies, cardiovascular diseases and many others. Approximately 20% of the US population have this condition, but most are not aware of it. Understanding the causes and mechanisms of CHIP and how these cells interact with cells of other tissues will provide critical insights into disease development and evolution.

In this panel discussion webinar, speakers will discuss the growing interest in this topic and a few example studies looking at how this condition arises and transforms into a disease. Dr. Ross Levine of Memorial Sloan Kettering Cancer Center (MSKCC) will first discuss the clinical manifestations of clonal hematopoiesis, and mechanisms underlying its development as well as its role in clonal evolution toward leukemia. Then he will invite two other speakers, Dr. Kelly Bolton of Washington University of St. Louis and Dr. Jyoti Nangalia of Wellcome Sanger Institute, for an interactive panel discussion that will offer key insights and diverse perspectives on CHIP as an important risk factor and its clinical impact.

Panelists:

• Ross L. Levine, MD, Memorial Sloan Kettering Cancer Center
• Kelly Bolton, MD, PhD, Washington University of St. Louis
• Jyoti Nangalia, PhD, Wellcome Sanger Institute

Register

Mission Bio webinar CHIP detection
Mission Bio logotype

Emerge Webinar Series Episode 7

Thursday March 31 at 4 pm (Amsterdam, Berlin, Stockholm)
Defining Proteome Dynamics in the Aging Proteome with Novel Computational Approaches

Register

Nathan Batisty, NIH, National Institute of Aging

Loss of protein homeostasis is a hallmark of aging and age-related conditions, including neurodegeneration, sarcopenia, and type 2 diabetes. However, alterations in markers of proteostasis machinery do not necessarily reflect rates of protein turnover. Therefore, methods to measure the turnover rates of proteins directly, rather than surrogate measurements of translation and degradation machinery, are critically needed to accurately examine the stability of the proteome during aging and disease processes.
The development of versatile computational tools on widely accessible, open-source platforms is needed to make this approach more user-friendly.
Here, we introduce a new computational tool – TurnoveR – for the accurate calculation of protein turnover rates from mass spectrometry analysis of metabolic labeling experiments in the Skyline software platform.
Using data generated from metabolic labeling of mice with heavy leucine in independent experiments, we demonstrate how this tool enables the calculation of protein turnover rates seamlessly within a Skyline workspace using raw data acquired on multiple mass spectrometric platforms and derive new biological insights into age-related diseases.

Register

ReSyn Biosciences webinar
MagReSyn technology
Mission Bio webinar
Mission Bio webinar

Clonal heterogeneity in ALL at diagnosis and during chemotherapy treatment detected by single-cell sequencing

Available on demand

Acute lymphoblastic leukemia (ALL) is an aggressive leukemia that occurs most frequently in children and is characterized by the presence of few chromosomal rearrangements and additional mutations. In this webinar, the second in a “Meet the Authors” series sponsored by Mission Bio, Jan Cools of the VIB Center for Cancer Biology in Leuven, Belgium will discuss the application of single-cell analysis to determine the clonal heterogeneity of the leukemia cells of ALL cases at diagnosis.

Dr. Cools’ lab used single-cell targeted DNA sequencing (Tapestri, Mission Bio) and single-cell RNA-sequencing (10x Genomics) to determine the clonal heterogeneity of the leukemia cells of 20 ALL cases at diagnosis and monitored the clonal evolution during chemotherapy treatment. Specifically, the lab designed a custom ALL panel and obtained accurate single-nucleotide variant and small insertion-deletion mutation calling for 305 amplicons covering 110 genes in about 4400 cells per sample and time point. Bone marrow and/or blood samples from 12 B-cell ALL and eight T-cell ALL patients were analyzed.

Dr. Cools will discuss how single-cell DNA amplicon sequencing is a sensitive assay to detect clonal architecture and evolution of the malignant cells in ALL, and present his findings published in the Blood paper, “Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia.”

Available on demand

Mission Bio ALL
Mission Bio logotype

Watch webinar on demand:

Laminar Wash enables single-cell multiomics and cell hashing in studies with limited numbers of cells

Watch the acknowledged webinar on demand

Professor Mats Bemark, Ph.D.‘s lab at the University of Gothenburg in Sweden studies how the immune system responds to respiratory infections, such as SARS-CoV-2 and influenza. His research focuses on interrogating these interactions at mucosal layers using advanced analytical methods, including flow cytometry and single-cell transcriptomics (scRNA-seq). A key to unlocking the potential of these studies is addressing sample prep challenges, particularly when starting cell numbers are limited.

Topics covered:

  • How to expand scRNA-seq immunology studies with TotalSeq antibodies for multiomics and cell hashing
  • Why proper cell washing is integral to study success
  • The challenges researchers face with a limited number of cells in a given sample
  • How Laminar Wash technology enabled TotalSeq labeling of antigen-specific lymphocytes in a study of mucosal immunology.


Get information about Laminar Wash™ for Single-Cell Sequencing

Curiox Laminar Wash CITE-Seq webinar
Curiox logo

Webinar:

Laminar Wash enables single-cell multiomics and cell hashing in studies with limited numbers of cells

Tuesday 19th October 11 am Eastern (17:00 Copenhagen)

Thursday 21st October 9 am Central Europe live Q&A

Watch on-demand

Professor Mats Bemark, Ph.D.‘s lab at the University of Gothenburg in Sweden studies how the immune system responds to respiratory infections, such as SARS-CoV-2 and influenza. His research focuses on interrogating these interactions at mucosal layers using advanced analytical methods, including flow cytometry and single-cell transcriptomics (scRNA-seq). A key to unlocking the potential of these studies is addressing sample prep challenges, particularly when starting cell numbers are limited.

Webinar attendees will learn:

  • How to expand scRNA-seq immunology studies with TotalSeq antibodies for multiomics and cell hashing
  • Why proper cell washing is integral to study success
  • The challenges researchers face with a limited number of cells in a given sample
  • How Laminar Wash technology enabled TotalSeq labeling of antigen-specific lymphocytes in a study of mucosal immunology.


Dr. Bemark will be available for a Live Q&A on 21 October at 9AM Central Europe time (15:00 Singapore time). Please use the link below to register for the Live Q&A; we will inform you when the recording is posted to the Curiox website beforehand.


Get information about Laminar Wash™ for Single-Cell Sequencing

Curiox single cell webinar
Laminar Wash technology
Curiox logo

Webinar:
Navigating through the IVDR Directive and utilising Qnostics within the molecular laboratory

Register

Thursday October 14 at 10 am (CET)

During this webinar our presenters will focus on navigating the IVDR directive and how best to tackle this new initiative. Additionally, our guest speakers will also present a valuable case which focuses specifically on the validation of a direct PCR machine utilising the Qnostics SARS-CoV-2 Analytical Q Panel.

 

Register

Qnostics IVDR webinar
Qnostics IVDR webinar

Emerge Webinar Series Episode 4

Automated and ultra-sensitive workflows for large-scale quantitative phosphoproteomics

Friday October 7, 18:00 CET conference start, 21:05 CET presentation start 

Register

Florian Harking, NNF Center for Protein Research, Olsen Group, University of Copenhagen, Denmark

Phosphorylation is one of the most common post-translational modifications. It plays a key role for intra-cellular signal transduction and is known to be involved in numerous disease mechanisms. Current LC-MS/MS based workflows focusing on identifying phosphorylation are aimed at processing high sample quantities at low throughput. At the same time, a number of clinical sample types, are limited by their sample amount, and less so the total number of samples. To address this discrepancy, significant efforts have been made in the last few years regarding the analysis of low-input sample preparation and automation. Florian will outline some of these efforts while illustrating the benefits of using automated sample preparation for a more streamlined and reproducible workflow.

Register

Emerge Resyn Bioscience webinars
Florian Harking webinar
SUMS-RAS

Emerge Webinar Series Episode 3
Wednesday July 28 at 17:00 CEST

Controls for Quantitative Proteomics (AKA How to Mass Spec Responsibly)

Register

Julia Robbins, Genome Sciences Department, University of Washington, Seattle

The presentation will focus on the application of rigorous controls in quantitative proteomics to actively assess and validate the integrity of experimental methods and quality of data.
Julia attended the University of Washington, graduating with a Bachelor of Science in Biology from 2013-2018. She joined the MacCoss Lab in January of 2018, where her work focuses on the application of quantitative proteomics to investigate neurodegenerative and aging-related disease in mice models and humans, with an emphasis on developing robust and high-throughput methods of sample preparation and data acquisition.

Register

Emerge Resyn Bioscience webinars
ReSyn Emerge Webinar

Webinar: A Next Generation Solution to Quality and Efficient Sample Prep for Single-Cell Multiomics Precision Oncology

Tuesday July 27 2021, 5 am – 6 am (CEST)

Register

Single-cell sequencing and multiomics analysis can be powerful tools across the therapy development pipeline, from discovery to diagnostics. The weak signal-to-noise inherent to these methods demands stringent and careful sample preparation, particularly when those samples come from cancer patients.

We are pleased to host Jonathan Scolnick, Ph.D., Founder and Chief Science Officer at Proteona, a precision oncology company based in Singapore. Proteona uses insights from single-cell multiomics measurements to improve cancer patient care. Joining Dr. Scolnick is Chyan Ying Ke, Ph.D., Associate Director of Bioapplications at Curiox. Dr. Ke leads the Curiox R&D team in Singapore.

Webinar attendees will learn:

– How Proteona approaches single-cell multiomics
– Insights gleaned from single-cell analysis for precision oncology
– Specific workflow challenges associated with single-cell multiomics
– How Curiox Laminar Wash™ technology addresses single-cell ‘omics sample prep
– How Curiox enables single-cell multiomics data collection at Proteona

The timing of the live event is tailored for our Asia-Pacific audience. Regardless of your time zone, we encourage all interested attendees to register, leave a question or comment in the field below, and watch the webinar on-demand shortly after its conclusion.

Register

Get information about Laminar Wash™ for Single-Cell Sequencing

Curiox Proteona Single-Cell Sequencing
Laminar Wash technology
Curiox logo

Webinar: Clinical Data Interpretation Service in NGS Workflows

Celemics & Strand Life Sciences Bioinfomratics Solution Service

Webinar recording

Celemics provides robust clinical interpretation services through Strand pipeline that combines bioinformatics algorithms, public data from external sources/knowledge databases, visualization interfaces and reporting capabilities, enabling the user to analyze the NGS data and generate clinical report from Celemics panels, for individual samples.

Webinar recording

Celemics Clinical Interpretation Service Flyer

Celemics Strand webinar

Emerge Webinar Series Episode 2
Wednesday June 30 at 17:00 CEST

High-throughput spatial-temporal proteomics for the study of phospho-signaling dynamics

Register

Dr. Ana Martinez del Val
Novo Nordisk Foundation Center for Protein Research, Denmark

The presentation will focus on the application of high-throughput spatial-temporal proteomics workflows for the study of phospho-signaling dynamics.

Dynamic changes in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry-based proteomics in combination with subcellular fractionation can provide comprehensive maps of spatio-temporal regulation of cells, but involves laborious methods that did not include phospho-proteome analysis.

Ana will present a high-throughput workflow, based on sequential cell fractionation, to profile the global proteome and phospho-proteome dynamics across six distinct subcellular fractions. The workflow was benchmarked by studying spatio-temporal EGFR phospho-signaling dynamics in-vitro (HeLa cell cultures) and in-vivo in mouse tissues, and was also employed to assess the spatio-temporal events in response to stress related signaling, such as hyperosmotic shock, revealing cellular relocation of ribosomal proteins.

Register

Emerge Resyn Bioscience webinars
Emerge Resyn Bioscience webinars

Ana obtained her PhD at the Proteomics Unit in the Spanish National Cancer Research Center, where she was working on quantitative proteomics and phosphoproteomics applied to stem cell biology. In 2019 she joined the lab of Jesper Olsen at the Novo Nordisk Foundation Center for Protein Research in Copenhagen, where she is working on further applications of mass spectrometry-based proteomics to study signaling and disease.

Emerge Webinar Series Episode 1
Wednesday June 2 at 16:00 CEST

Uncovering the Enzymology and Function of Protein Methylation through Mass Spectrometry based Proteomics

Dr. Magnus Jakobsson, Lund university

In support of emerging researchers, we are introducing the EMERGE webinar series with a specific focus on highlighting novel methods and solutions that labs are implementing to tackle the challenges associated with applying omics technologies in a routine way.

At ReSyn Biosciences we focus on efficiency and reproducibility to develop novel workflows for biological Mass Spectrometry and Bioseparation.

Register

Dr Jakobsson received a PhD in 2013 from Oslo University with his thesis entitled: “Characterization of novel human protein methyltransferases”, and subsequently joined the the laboratory of Dr Jesper V Olsen at the Novo Nordisk Foundation Centre for Protein Research, Copenhagen University.

Since 2019 Magnus has been based at Lund University, where he is a co-leader of the Proteoforms@LU MS platform, focusing on post translational modifications and protein variants. He is also a research group leader at the department of Immunotechnology, where his research focuses on aspects covering both basic and translational research, including the development of proteomics workflows for analysis of “orphan” PTMs, the quantitative analysis of proteins and their regulatory PTMs for developing new cancer diagnostics.

Emerge Resyn Bioscience webinars

Live Demo of Acusera 24•7 QC Management Software

Meeting link

Tuesday May 25, 1 pm CEST

Following on from our successful webinar, Randox Laboratories are pleased to invite you to an online demo of our Acusera 24•7 QC Management Software.

Throughout the previous webinar, key speaker Margaret Le Roux highlighted the benefits of implementing a quality control software in a laboratory, specifically focusing on the use of sigma metrics, %bias, total error, uncertainty of measurement and other statistical reports.

An automated QC software, such as Acusera 24•7, can help to enhance performance assessment, improve QC strategy and meet regulatory requirements. This demo session aims to provide an insight to our state-of-the-art software package.

Acusera 24.7 live demo

Webinar: The Need for Robust Molecular Quality Assurance in the Wake of the Pandemic

Register

Wednesday May 26, 2 pm CEST

This educational webinar will discuss topics surrounding the importance of third party molecular Quality Control and External Quality Assessment, as well as the clinical impacts of good or poor QC management. Furthermore, Randox Molecular Product Specialists will detail our extensive product ranges of Qnostics (Molecular QC) and QCMD (Molecular EQA).

Wednesday May 26, 2 pm CEST

Qnostics Brochure

Qnostics webinar
Qnostics

Webinar on the utilisation of Quality Control software and sigma metrics for the identification of performance issues.

Register

Tuesday May 18, 1 pm CEST

Acusera 24•7 is an automated QC software which helps to enhance performance assessment, improve QC strategy and meet regulatory requirements.

The webinar will specificlaly focus on the use of sigma metrics, %bias, total error, uncertainty of measurement and other statistical reports.

Tuesday May 18, 1 pm CEST

Acusera 24.7 Brochure

Acusera 24.7 webinar
Randox quality control

Webinar:
Towards Standardizing Flow Cytometry Sample Preparation Workflows without Centrifugation

Register

Wednesday May 13, 5 pm CEST

How much further along would you be if your cell and single nuclei sample prep methods were more consistent, less labor-intensive, and retained more precious material? We’ve teamed up with flowcytometryUK and Charles River Laboratories to discuss how Laminar Wash technology can help standardize, optimize, and improve cell and single nuclei suspension prep as the front-end to generating quality flow cytometry data.

Please join us live on Thursday 13 May for a webinar featuring Noma Ngwenya, Application Scientist at Curiox Biosystems, and Christoph Eberle, Ph.D., Principal Scientist II at Charles River, for an informative webinar, featuring:

  • An introduction to Laminar Wash technology in support of flow cytometry
  • Improvements in single nuclei retention and antibody consumption at Cerevance, a clinical-stage CNS therapeutics company
  • Examples of how Charles River is using Laminar Wash to standardize its flow cytometry sample prep

Date: Wednesday May 13 2021
Time: 5:00 pm CEST

Curiox webinar CRL
Stop losing cells

Mission Bio Webinar

How Do You Gain Insight into Disease Evolution?

Register to Webinar
Monday April 19 at 9 am CEST

We’re delighted to be hosting a webinar with FIMM, where they tackle some of the most difficult challenges in genomic research by using information from genome sequences to advance the understanding of biology and improve health.

As a pioneer in high-throughput single-cell multi-omic analysis, Mission Bio has developed a platform to genotype and phenotype from the same cell.

During the webinar we will share:

  • General Tapestri Overview including SNV, CNV, and protein capabilities
  • Hematology applications

Date: Monday, April 19, 2021
Time: 9:00 AM CET

MissionBio webinar
Mission Bio webinars

Reliable Gene Silencing with Exceptional siRNA Specificity by High Complexity siPOOLs

Thursday April 15 2021 at 3 pm CEST

siRNA pools (siPOOLs) are high complexity pools of 30 optimally-designed siRNAs that were demonstrated to efficiently remove off-target effects and improve reliability of results (Hannus et al., 2014).

siPOOLs are suited for use against coding or long non-coding RNAs, selected isoforms or closely-related genes, and can be applied in combination to study synergistic gene interactions (Welsbie et al., 2017).

siPOOLs are ideal tools in drug discovery for target validation and target identification with custom or ready-made siPOOL libraries.

Register

siPOOL webinar

Qnostics Quality Controls for Molecular Diagnostic Assays in Infectious Disease

Wednesday March 24 at 10-11 am (CET)

Importance of Independent Third Party Controls

This discussion will provide tangible examples on how to successfully incorporate the use of a variety of different Qnostics controls into laboratories carrying out molecular diagnostic testing:

Test for the dynamic range of a molecular assay using Analytical Q Panels

Test the comparable of Methods vs Robotic systems using Molecular Q Panels

Undertake equipment validations and staff training using Medium Q Controls.

Register

Presented by Dwaine R. Vance BSc (Hons), DIS, PhD.

Qnostics SARS-CoV-2 Controls

Mission Bio Technology and Applications
New Single Cell Genomics and Multiomics Service

Register to Webinar
Wednesday March 10 at 10 am CET

We´re delighted to be hosting a webinar with SciLifeLab clinical Genomics Facility, where they tackle some of the most difficult challenges in genomic research by using information from genome sequences to advance the understanding of biology and improve health.

MissionBio webinar

Centrifuge-Free Automation of Suspension Cell Sample Preparation
Webinar Wednesday February 24 10 am (EST)

Automating cell wash workflows with a centrifuge is challenging and expensive.

Alternatively, Laminar Wash™ technology offers a gentle, reproducible, and high-throughput alternative to preparing suspension cell samples without subjecting them to damaging gravitational forces.

Join us to find out how Laminar Wash:

Overcomes the challenges of automating sample prep

Offers several integration options to streamline your laboratory workflow

Improves cell suspension sample quality for downstream analysis

Register

Speakers:
Malcolm Crook, PhD, Technical Director, Peak Analysis & Automation
Ann Wang, Field Application Specialist, Curiox Biosystems

Laminar Wash video

LabLife Nordic AB

Rättarens väg 9
SE-182 34 Danderyd
SWEDEN
+46 8 755 39 14